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Encyclopedia of Behavioral Medicine

Living Edition
| Editors: Marc Gellman

Adipose Tissue Dysfunction

  • William Trim
  • Dylan Thompson
  • James E. TurnerEmail author
Living reference work entry
DOI: http://doi.org/10.1007/978-1-4614-6439-6_101903-1
  • 140 Downloads

Synonyms

Definition

The impairment of normal adipose tissue function, characterized by changes to the structure and cellular composition of the tissue microenvironment, resulting in abnormal secretions derived predominantly, but not exclusively, from adipocytes (i.e., fat cells) and localized immune cells. These changes can be instigated by energy imbalance and are commonly observed with aging and obesity. The result is expansion of abdominal subcutaneous and visceral (intra-abdominal) adipose tissue, but for women, especially, gluteofemoral (hip and legs) adipose stores. The broader consequences are local and systemic inflammation, impaired tissue-specific and whole-body insulin sensitivity, and poor metabolic control. Thus, adipose tissue dysfunction is implicated in the pathogenesis of type-II diabetes, hypertension, cancer, cognitive dysfunction, and atherosclerosis.

Description

Background and Overview

365体育网站Traditionally, adipose tissue was considered an...

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References and Further Reading

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  2. Chandran, M., Phillips, S. A., Ciaraldi, T., & Henry, R. R. (2003). Adiponectin: More than just another fat cell hormone? Diabetes Care, 26(8), 2442–2450.  .
  3. Donath, M. Y., & Shoelson, S. E. (2011). Type 2 diabetes as an inflammatory disease. Nature Reviews. Immunology, 11(2), 98–107.  .
  4. Frayn, K. N., Karpe, F., Fielding, B. A., Macdonald, I. A., & Coppack, S. W. (2003). Integrative physiology of human adipose tissue. International Journal of Obesity and Related Metabolic Disorders, 27(8), 875–888.  .
  5. Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., & Shimomura, I. (2007). Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes, 56(4), 901–911.  .
  6. Hotamisligil, G. S. (2006). Inflammation and metabolic disorders. Nature, 444(7121), 860–867.  .
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  8. Item, F., & Konrad, D. (2012). Visceral fat and metabolic inflammation: The portal theory revisited. Obesity Reviews, 13(Suppl 2), 30–39.  .
  9. Karpe, F., Dickmann, J. R., & Frayn, K. N. (2011). Fatty acids, obesity, and insulin resistance: Time for a reevaluation. Diabetes, 60(10), 2441–2449.  
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  16. Pal, M., Febbraio, M. A., & Whitham, M. (2014). From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation. Immunology and Cell Biology, 92(4), 331–339.  .
  17. Pasarica, M., Gowronska-Kozak, B., Burk, D., Remedios, I., Hymel, D., Gimble, J., Ravussin, E., Bray, G. A., & Smith, S. R. (2009a). Adipose tissue collagen VI in obesity. Journal of Clinical Endocrinology and Metabolism, 94(12), 5155–5162.  .
  18. Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009b). Reduced adipose tissue oxygenation in human obesity. Evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes, 58(3), 718–725.  .
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  21. Schipper, H. S., Prakken, B., Kalkhoven, E., & Boes, M. (2012). Adipose tissue-resident immune cells: Key players in immunometabolism. Trends in Endocrinology and Metabolism, 23(8), 407–415.  .
  22. Stout, M. B., Justice, J. N., Nicklas, B. J., & Kirkland, J. L. (2017). Physiological aging: Links among adipose tissue dysfunction, diabetes, and frailty. Physiology, 32(1), 9–19.  .
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  25. Thompson, D., Manolopoulos, K., & Bouloumie, A. (2012). Arterio-venous differences in peripheral blood mononuclear cells across human adipose tissue and the effect of adrenaline infusion. International Journal of Obesity, 36(9), 1256–1258.  .
  26. Travers, R. L., Motta, A. C., Betts, J. A., Bouloumie, A., & Thompson, D. (2015). The impact of adiposity on adipose tissue-resident lymphocyte activation in humans. International Journal of Obesity, 39, 762–769.  .
  27. Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003). Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation, 112(12), 1796–1808.  .
  28. Wertheimer, E., & Shapiro, B. (1948). The physiology of adipose tissue. Physiological Reviews, 28(4), 451–464.

Copyright information

© Springer Science+Business Media LLC 2018

Authors and Affiliations

  • William Trim
    • 1
  • Dylan Thompson
    • 1
  • James E. Turner
    • 1
    Email author
  1. 1.Department for HealthUniversity of BathBathUK

Section editors and affiliations

  • Anna C. Phillips
    • 1
  1. 1.School of Sport, Exercise & Rehabilitation SciencesUniversity of BirminghamBirminghamUK