Adenosquamous Carcinoma, Lung
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Mixed glandular and squamous carcinoma
An invasive carcinoma showing components of both invasive adenocarcinoma and squamous cell carcinoma. The lesser component should still comprise at least 10% of the tumor overall. Thus, adenosquamous carcinoma is a diagnosis that can only be made definitively in surgically resected cases where the whole tumor can be examined.
365体育网站Adenosquamous carcinoma of the lung is a relatively rare subtype, although figures for incidence vary widely due, historically, to a range of different diagnostic criteria being used to make the diagnosis. Figures quoted range from 0.4% to 5% of lung carcinomas. Given that it is a diagnosis that may only be confirmed in surgically resected series, the true incidence in all lung cancer patients, the majority of whom never have a surgical resection, could be rather different. As with most other nonsmall cell carcinomas (NSCLC), there is an association with smoking tobacco.
References and Further Readings
- Watababe, Y., Tsuta, K., Kusumoto, M., et al. (2014). Clinicopathological features and computed tomographic findings of 52 surgically resected adenosquamous carcinomas of the lung. Annals of Thoracic Oncology, 97, 245–251.
- Watababe, Y., Shiraishi, K., Takahashi, F., et al. (2015). Biomarker expression and druggable genomic alterations for development of an appropriate therapeutic protocol for pulmonary adenosquamous carcinoma. Histopathology, 66, 939–948.
- Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO Press.