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365体育网站Invasive adenocarcinoma is a malignant epithelial tumor showing glandular differentiation, mucin production, or “pneumocyte marker” expression determined by immunohistochemistry (IHC). Patterns of glandular differentiation which are associated with adenocarcinoma subtypes are lepidic, acinar, papillary, micropapillary, and solid.
Incidence and Etiology
Lung cancer in general is the commonest cause of lung cancer globally, and adenocarcinoma is the most common form of lung cancer in global terms. In the USA, the lung cancer incidence rate is approximately 35 cases per 100,000 person-years, but such figures are of questionable value given the considerable variations, largely due to regional variance in tobacco consumption. In several European countries, this figure can...
References and Further Reading
- Devarakona, S., Morgensztern, D., & Govindan, R. (2015). Genomic alterations in lung adenocarcinoma. Lancet Oncology, 16, e342–e351.
- Greulich, H. (2011). The genomics of lung adenocarcinoma: Opportunities for targeted therapies. Genes & Cancer, 1, 1200–1210.
- Imielinski, M., Berger, A. H., Hammerman, P., et al. (2012). Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell, 150, 1107–1120.
- Kerr, K. M. (2009). Pulmonary adenocarcinoma: Classification and reporting. Histopathology, 54, 12–27.
- Travis, W. D., Brambilla, E., Noguchi, M., et al. (2011). International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. Journal of Thoracic Oncology, 6(2), 244–285.
- Travis, W. D., Brambilla, E., Noguchi, M., et al. (2013). Diagnosis of lung cancer in small biopsies and cytology: Implications of the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification. Archives of Pathology & Laboratory Medicine, 137, 668–684.
- Travis, W. D., Brambilla, E., Burke, A. P., Marx, A., & Nicholson, A. N. (Eds.). (2015). WHO classification of tumours of the lung, pleura, thymus and heart. Geneva: WHO press.