Amyloidosis in the Genitourinary Tract
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It is a chronic disease with extracellular amyloid deposits in the genitourinary organs.
365体育网站Primary: Commonly AL type amyloid typically associated with some lymphoproliferative disorders.
Secondary: AA type amyloid, linked to various chronic inflammatory diseases (rheumatoid arthritis, Crohn disease, ankylosing spondylitis, myeloma, and familial Mediterranean fever).
Localized: Deposition of AL type amyloid of unknown etiology.
365体育网站Familial: Frequently associated with Transthyretin mutations.
The true incidence of systemic and localized amyloidosis in genitourinary organs is not currently available.
365体育网站Systemic: Men are mainly affected by AL amyloidosis, women by AA amyloidosis.
365体育网站Localized: No sex prevalence.
Systemic: Kidney most commonly affected (Chitale et al. 2007).
Localized: Renal pelvis and lower genitourinary tract, particularly urinary bladder but also urethra (Monge et al.
References and Further Reading
- Caballero Martínez, M. C., Gomez, M., Angel Cuesta Alcalá J, et al. (2003). Amyloidosis of the seminal vesicles: Clinical and pathological review of 8 cases diagnosed from surgical specimens. Archivos Españoles de Urología, 56, 431.
- Chitale, S., Morsey, M., Peat, D., & Webb, R. (2007). Amyloidosis of lower genitourinary tract: A review. European Urology Supplements, 5, 70–76.
- Jain, M., Kumari, N., Chhabra, P., & Gupta, R. (2008). Localized amyloidosis of urinary bladder: A diagnostic dilemma. Indian Journal of Pathology & Microbiology, 51, 247–249.
- Li, Y., Mongan, J., Behr, S. C., et al. (2016). Beyond prostate adenocarcinoma: Expanding the differential diagnosis in prostate pathologic conditions. Radiographics, 36, 1055–1075.
- Monge, M., Chauveau, D., Cordonnier, C., et al. (2011). Localized amyloidosis of the genitourinary tract: Report of 5 new cases and review of the literature. Medicine, 90, 212–222.